Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer
WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
Overview on clinical relevance of intra-tumor heterogeneity
G Stanta, S Bonin - Frontiers in medicine, 2018 - frontiersin.org
Today, clinical evaluation of tumor heterogeneity is an emergent issue to improve clinical
oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer …
oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer …
Machine learning and network analyses reveal disease subtypes of pancreatic cancer and their molecular characteristics
Given that the biological processes governing the oncogenesis of pancreatic cancers could
present useful therapeutic targets, there is a pressing need to molecularly distinguish …
present useful therapeutic targets, there is a pressing need to molecularly distinguish …
Epigenetic alterations in pancreatic cancer metastasis
SS Wang, J Xu, KY Ji, CI Hwang - Biomolecules, 2021 - mdpi.com
Pancreatic cancer is the third leading cause of cancer-related deaths in the United States.
Pancreatic ductal adenocarcinoma (PDA) is the most common (90%) and aggressive type of …
Pancreatic ductal adenocarcinoma (PDA) is the most common (90%) and aggressive type of …
ELMER v. 2: an R/Bioconductor package to reconstruct gene regulatory networks from DNA methylation and transcriptome profiles
Motivation DNA methylation has been used to identify functional changes at transcriptional
enhancers and other cis-regulatory modules (CRMs) in tumors and other disease tissues …
enhancers and other cis-regulatory modules (CRMs) in tumors and other disease tissues …
Survival analysis of multi-omics data identifies potential prognostic markers of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the most common and among the deadliest of
pancreatic cancers. Its 5-year survival is only∼ 8%. Pancreatic cancers are a …
pancreatic cancers. Its 5-year survival is only∼ 8%. Pancreatic cancers are a …
DNA-methylation signature accurately differentiates pancreatic cancer from chronic pancreatitis in tissue and plasma
Y Wu, I Seufert, FN Al-Shaheri, R Kurilov, AS Bauer… - Gut, 2023 - gut.bmj.com
Objective Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Differentiation
from chronic pancreatitis (CP) is currently inaccurate in about one-third of cases …
from chronic pancreatitis (CP) is currently inaccurate in about one-third of cases …
MYEOV increases HES1 expression and promotes pancreatic cancer progression by enhancing SOX9 transactivity
E Liang, Y Lu, Y Shi, Q Zhou, F Zhi - Oncogene, 2020 - nature.com
Emerging evidence indicates that myeloma overexpressed (MYEOV) is an oncogene and
plays crucial roles in multiple human cancers. However, its roles in the development of …
plays crucial roles in multiple human cancers. However, its roles in the development of …
Open-source curation of a pancreatic ductal adenocarcinoma gene expression analysis platform (pdacR) supports a two-subtype model
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease for which potent
therapies have limited efficacy. Several studies have described the transcriptomic landscape …
therapies have limited efficacy. Several studies have described the transcriptomic landscape …
The emerging roles of ATP-dependent chromatin remodeling complexes in pancreatic cancer
Pancreatic cancer is an aggressive cancer with low survival rates. Genetic and epigenetic
dysregulation has been associated with the initiation and progression of pancreatic tumors …
dysregulation has been associated with the initiation and progression of pancreatic tumors …