Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace
normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease …

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays a pivotal
role in mediating cell size and mass, proliferation, and survival. mTOR has also emerged as …

ContextChronic kidney disease is a growing public health problem. Screening for early
identification could improve health but could also lead to unnecessary harms and excess …

In the last 25 years, a number of animal models, mainly rodents, have been generated with
the goal to mimic cholestatic liver injuries and, thus, to provide in vivo tools to investigate the …

Cilia are highly conserved organelles that have diverse motility and sensory functions.
Recent discoveries have revealed that cilia also have crucial roles in cell signaling …

Primary cilia are implicated in the pathogenesis of autosomal-dominant polycystic kidney
disease (ADPKD), which results from defects in polycystin-1 (PC1), but the function of PC1 …

The transmission system of" frequency modulation"(transmission by variation of the
frequency of the radiated wave) is mathematically analyzed, and the width of the band of …

Polycystic kidney disease (PKD) is an inherited disorder that is characterized by the
accumulation of cysts in the renal parenchyma and progressive decline in renal function …

The clinical use of conventional ultrasonography (US) in autosomal dominant polycystic
kidney disease (ADPKD) is currently limited by reduced diagnostic sensitivity, especially in …

Transient receptor potential vanilloid (TRPV) channels are widely expressed in both sensory
and nonsensory cells. Whereas the channels display a broad diversity to activation by …