Liquid biopsy, a minimally invasive approach, is a highly powerful clinical tool for the real‐
time follow‐up of cancer and overcomes many limitations of tissue biopsies. Epigenetic …

Aberrant DNA methylation is an epigenetic hallmark of melanoma, known to play important
roles in melanoma formation and progression. Recent advances in genome-wide …

Background Epigenetic marks are heritable, influenced by the environment, direct the
maturation of T lymphocytes, and in mice enhance the development of allergic airway …

Purpose: Pituitary adenomas are one of the most common benign neoplasms of the central
nervous system. Although emerging evidence suggests roles for both genetic and …

Background Breast cancer is a highly heterogeneous disease resulting in diverse clinical
behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that …

Transcriptional regulation requires the binding of transcription factors (TFs) to short
sequence-specific DNA motifs, usually located at the gene regulatory regions. Interestingly …

Extensive and multi-dimensional data sets generated from recent cancer omics profiling
projects have presented new challenges and opportunities for unraveling the complexity of …

Metastasis is responsible for most cancer-related deaths, and, among common tumor types,
melanoma is one with great potential to metastasize. Here we study the contribution of …

Optimal treatment of brain metastases is often hindered by limitations in diagnostic
capabilities. To meet this challenge, here we profile DNA methylomes of the three most …

Over the last 20-80 million years the mammalian placenta has taken on a variety of
morphologies through both divergent and convergent evolution. Recently we have shown …