Transcription factors as readers and effectors of DNA methylation
Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …
base-pair resolution under various physiological conditions. Many aberrant or differentially …
Sensitivity of transcription factors to DNA methylation
Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …
states throughout organism development. Epigenetics modifications, such as DNA …
Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation
Somatic mutations in cancer genes have been detected in clonal expansions across healthy
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …
human tissue, including in clonal hematopoiesis. However, because mutated and wild-type …
Competition between DNA methylation and transcription factors determines binding of NRF1
Eukaryotic transcription factors (TFs) are key determinants of gene activity, yet they bind only
a fraction of their corresponding DNA sequence motifs in any given cell type. Chromatin has …
a fraction of their corresponding DNA sequence motifs in any given cell type. Chromatin has …
[HTML][HTML] Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role
KS Crider, TP Yang, RJ Berry, LB Bailey - Advances in nutrition, 2012 - Elsevier
ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …
regulation and development. The vitamin folate is a key source of the one carbon group …
[HTML][HTML] An expansive human regulatory lexicon encoded in transcription factor footprints
Regulatory factor binding to genomic DNA protects the underlying sequence from cleavage
by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting …
by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting …
Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies
Background During the past 5 years, high-throughput technologies have been successfully
used by epidemiology studies, but almost all have focused on sequence variation through …
used by epidemiology studies, but almost all have focused on sequence variation through …
Widespread plasticity in CTCF occupancy linked to DNA methylation
CTCF is a ubiquitously expressed regulator of fundamental genomic processes including
transcription, intra-and interchromosomal interactions, and chromatin structure. Because of …
transcription, intra-and interchromosomal interactions, and chromatin structure. Because of …
[HTML][HTML] The roles of human DNA methyltransferases and their isoforms in shaping the epigenome
A DNA sequence is the hard copy of the human genome and it is a driving force in
determining the physiological processes in an organism. Concurrently, the chemical …
determining the physiological processes in an organism. Concurrently, the chemical …
[HTML][HTML] 8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions
X Ba, I Boldogh - Redox biology, 2018 - Elsevier
Oxidative stress and the resulting damage to genomic DNA are inevitable consequences of
endogenous physiological processes, and they are amplified by cellular responses to …
endogenous physiological processes, and they are amplified by cellular responses to …