Cryptococcus neoformans is an opportunistic pathogenic yeast that causes serious
infections, most commonly of the central nervous system (CNS). C. neoformans is mainly …

Fungi are opportunistic pathogens that infect immunocompromised patients and are
responsible for an estimated 1.5 million deaths every year. The antifungal innate immune …

Cryptococcosis is a potentially lethal disease that is primarily caused by the fungus
Cryptococcus neoformans, treatment options for cryptococcosis are limited. Here, we show …

Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced
intracellular signal cascades are indispensable for the initiation and regulation of antifungal …

Cryptococcus species, the etiological agents of cryptococcosis, are encapsulated fungal
yeasts that predominantly cause disease in immunocompromised individuals, and are …

Development of vaccines against opportunistic infections is difficult as patients most at risk of
developing disease are deficient in aspects of the adaptive immune system. Here, we …

Combatting the ever-increasing threat from invasive fungal pathogens faces numerous
fundamental challenges, including constant human exposure to large reservoirs of species …

C-type lectin receptors (CLRs) are powerful pattern-recognition receptors that discern
'self'and 'non-self'in our body and protect us from invasive pathogens by mediating immune …

Most fungal species are harmless to humans and some exist as commensals on
mucocutaneous surfaces. Yet many fungi are opportunistic pathogens, causing life …

Upon Cryptococcus neoformans infection of the host lung, the fungus enters a nutrient poor
environment and must adapt to a variety of host-specific stress conditions (temperature …