Evidence is emerging that several diseases and behavioral pathologies result from defects
in gene function. The best-studied example is cancer, but other diseases such as …

Summry—Deregulation of gene expression is a hallmark of the cancer cell. Acquiring a new
profile of expressed proteins may enable the cell to re‐enter the cell cycle, or give them a …

We use hepatic cellular carcinoma (HCC), one of the most common human cancers, as a
model to delineate the landscape of promoter hypomethylation in cancer. Using a …

Aim: In the present study, we investigated whether global DNA methylation levels are
affected by mitochondrial DNA (mtDNA) variants, which are known to modulate …

A hallmark of cancer is aberrant DNA methylation, consisting of global hypomethylation and
regional hypermethylation of tumor suppressor genes. DNA methyltransferase inhibitors …

DNA methylation serves as the principal form of post-replicative epigenetic modification. It is
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …

The DNA methylation pattern is an important component of the epigenome that regulates
and maintains gene expression programs. In this paper, we test the hypothesis that …

Methylation of cytosines in CpG dinucleotides is the predominant epigenetic mark on
vertebrate DNA. DNA methylation is associated with transcriptional repression. The pattern …

OBJECTIVE: To review the current knowledge of the mechanism of DNA methylation, its
association with transcriptional silencing, possible mechanisms of hyper-and …

DNA methyltransferase 1 (DNMT1) catalyzes the post-replication methylation of DNA and is
responsible for maintaining the DNA methylation pattern during cell division. A long list of …