Histone variants, which generally differ in few amino acid residues, can replace core
histones (H1, H2A, H2B, and H3) to confer specific structural and functional features to …

The constant decline in fertility and older reproductive age is the major cause of low clinical
pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper …

The presence of an extra chromosome in the embryo karyotype often dramatically affects the
fate of pregnancy. Trisomy 16 is the most common aneuploidy in first-trimester miscarriages …

Purpose High frequency of aneuploidy in meiosis and cleavage stage coincides with waves
of epigenetic genome reprogramming that may indicate a possible association between …

Lysosomal storage diseases (LSDs) are a group of monogenic diseases characterized by
mutations in genes coding for proteins associated with the lysosomal function. Despite the …

Chromosomal mosaicism is a hallmark of early human embryo development. The last
decade yielded an enormous amount of information about diversity and prevalence of …

Maintaining a definite and stable pool of dividing stem cells plays an important role in organ
development. This process requires an appropriate progression of mitosis for proper spindle …

Recurrent pregnancy loss (RPL) is a clinical disorder defined by the occurrence of two or
more miscarriages and necessitates specialized medical care. RPL has a significant impact …

Androgenesis is an important chromosome set manipulation technique used in sex control
in aquaculture. Haploid embryos exhibit haploid syndrome with body abnormalities and …

In this study we presented several patients with genital infections during pregnancy,
perinatal infection, de novo genetics syndromes, sterility problems and spontaneous …