Tumor heterogeneity poses one of the greatest challenges to a successful treatment of
cancer. Tumor cell populations consist of different subpopulations that have distinct …

The critical role of dysregulated epigenetic pathways in cancer genesis, development, and
therapy has typically been established as a result of scientific and technical innovations in …

Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …

Simple Summary Drug resistance and insensitivity to treatments are the main challenges in
breast cancer therapy. Cancer-associated fibroblasts (CAFs) are heterogeneous stromal …

In bone biology, epigenetics plays a key role in mesenchymal stem cells'(MSCs)
commitment towards osteoblasts. It involves gene regulatory mechanisms governed by …

Autophagy is a critical regulator of cellular homeostasis and its dysregulation often results in
various disease manifestations, including cancer. Nimbolide, an active chemical constituent …

Fusarium is a species-rich group of mycotoxigenic plant pathogens that ranks as one of the
most economically important fungal genera in the world. During growth and infection, they …

Background Increasing life expectancy but also healthspan seems inaccessible as of yet but
it may become a reality in the foreseeable future. To extend lifespan, it is essential to unveil …

The field of epigenetics studies the complex processes that regulate gene expression
without altering the DNA sequence itself. It is well established that epigenetic modifications …

Cancer therapeutics is an ever-evolving field due to incessant demands for effective and
precise treatment options. Over the last few decades, cancer treatment strategies have …