The role of hypoxia-inducible factors in cardiovascular diseases
B Yu, X Wang, Y Song, G Xie, S Jiao, L Shi… - Pharmacology & …, 2022 - Elsevier
Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …
Hypoxia inducible factor as a therapeutic target for atherosclerosis
T Jain, EA Nikolopoulou, Q Xu, A Qu - Pharmacology & therapeutics, 2018 - Elsevier
Atherosclerosis is a highly prevalent disease that can significantly increase the risk of major
vascular events, such as myocardial or cerebral infarctions. The anoxemia theory states that …
vascular events, such as myocardial or cerebral infarctions. The anoxemia theory states that …
Mechanical activation of hypoxia-inducible factor 1α drives endothelial dysfunction at atheroprone sites
S Feng, N Bowden, M Fragiadaki… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—Atherosclerosis develops near branches and bends of arteries that are exposed
to low shear stress (mechanical drag). These sites are characterized by excessive …
to low shear stress (mechanical drag). These sites are characterized by excessive …
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …
Hypoxia-inducible factor-1α expression in macrophages promotes development of atherosclerosis
A Aarup, TX Pedersen, N Junker… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—Atherosclerotic lesions contain hypoxic areas, but the pathophysiological
importance of hypoxia is unknown. Hypoxia-inducible factor-1α (HIF-1α) is a key …
importance of hypoxia is unknown. Hypoxia-inducible factor-1α (HIF-1α) is a key …
Mutual antagonism of hypoxia-inducible factor isoforms in cardiac, vascular, and renal disorders
M Packer - Basic to Translational Science, 2020 - jacc.org
Summary Hypoxia-inducible factor (HIF)-1α and HIF-2α promote cellular adaptation to acute
hypoxia, but during prolonged activation, these isoforms exert mutually antagonistic effects …
hypoxia, but during prolonged activation, these isoforms exert mutually antagonistic effects …
Cholesterol and HIF-1α: dangerous liaisons in atherosclerosis
HIF-1α exerts both detrimental and beneficial actions in atherosclerosis. While there is
evidence that HIF-1α could be pro-atherogenic within the atheromatous plaque …
evidence that HIF-1α could be pro-atherogenic within the atheromatous plaque …
Hypoxia-inducible factor-1α: the master regulator of endothelial cell senescence in vascular aging
Aging is one of the hottest topics in biomedical research. Advances in research and
medicine have helped to preserve human health, leading to an extension of life expectancy …
medicine have helped to preserve human health, leading to an extension of life expectancy …
Oxidized low-density lipoprotein accumulation suppresses glycolysis and attenuates the macrophage inflammatory response by diverting transcription from the HIF-1α …
Lipid accumulation in macrophages (Mφs) is a hallmark of atherosclerosis, yet how lipid
accumulation affects inflammatory responses through rewiring of Mφ metabolism is poorly …
accumulation affects inflammatory responses through rewiring of Mφ metabolism is poorly …
Quality assessment and Q-markers discovery of Tongsaimai tablet by integrating serum pharmacochemistry and network pharmacology for anti-atherosclerosis benefit
Y Cheng, M Xiao, J Chen, D Wang, Y Hu, C Zhang… - Chinese Medicine, 2022 - Springer
Background The limited therapeutic outcomes of atherosclerosis (AS) have allowed,
traditional Chinese medicine has been well established as an alternative approach in …
traditional Chinese medicine has been well established as an alternative approach in …