Evidence is emerging that several diseases and behavioral pathologies result from defects
in gene function. The best-studied example is cancer, but other diseases such as …

▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …

DNA-methylation patterns are important for regulating genome functions, and are
determined by the enzymatic processes of methylation and demethylation. The …

The pattern of DNA methylation plays an important role in regulating different genome
functions. To test the hypothesis that DNA methylation is a reversible biochemical process …

DNA methylation is important for controlling the profile of gene expression and is catalyzed
by DNA methyltransferase (MTase), an enzyme that is abundant in brain. Because …

Prostate cancer is the most common noncutaneous malignancy and the second leading
cause of cancer death among men in the United States. DNA methylation and histone …

In previous studies, we documented increased citrullinated myelin basic protein (MBP) was
present in MBP isolated from multiple sclerosis (MS) normal appearing white matter …

Transformed cells are characterized by imbalances in metabolic routes. In particular,
different key enzymes of nucleotide metabolism and DNA biosynthesis, such as CTP …

Abstract Changes in gene expression that reset a cell program from a normal to a diseased
state involve multiple genetic circuitries, creating a characteristic signature of gene …

Nowadays, the mechanisms governing the occurrence of cancer are thought to be the
consequence not only of genetic defects but also of epigenetic modifications. Therefore …