Background Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-
related mortality in the world; however, the molecular mechanisms leading to hepatocyte …

The inhibitory activity of base-modified SAH analogues and the specificity of inhibiting
human DNMT1 and DNMT3b2 enzymes was explored. The 6-amino group was essential …

Background Inhibitor of Growth (ING) proteins are epigenetic “readers” that recognize
trimethylated lysine 4 of histone H3 (H3K4Me3) and target histone acetyl transferase (HAT) …

Epigenomic changes in DNA methylation patterns are evident in a variety of cancers,
including colorectal cancer (CRC). In addition, a large proportion of CRC tumors and cell …

Publisher Summary Deoxyribonucleic acid (DNA) methylation, a covalent modification of the
genome, is emerging as an important player in the regulation of gene expression. This …

DNA methylation patterns are generated during development by a sequence of methylation
and demethylation events. We have recently demonstrated that mammals bear a bona …

Cancer cell lines, which are cell cultures derived from tumor samples, represent one of the
least expensive and most studied preclinical models for drug development. Accurately …

Background Aberration in the pattern of DNA methylation is one of the hallmarks of cancer.
We present data suggesting that dysregulation of MBD2, a recently characterized member of …

DNA methylation is a major determinant of epigenetic inheritance. DNA methyltransferase 1
(DNMT1) is the enzyme responsible for the maintenance of DNA methylation patterns during …

Ectopic expression of DNA methyltransferase 1 (DNMT1) has been proposed to play an
important role in cancer. dnmt1 mRNA is undetectable in growth-arrested cells but is …