[HTML][HTML] Hyaluronic acid scaffolds for loco-regional therapy in nervous system related disorders
A Djoudi, R Molina-Peña, N Ferreira, I Ottonelli… - International Journal of …, 2022 - mdpi.com
Hyaluronic acid (HA) is a Glycosaminoglycan made of disaccharide units containing N-
acetyl-D-glucosamine and glucuronic acid. Its molecular mass can reach 10 MDa and its …
acetyl-D-glucosamine and glucuronic acid. Its molecular mass can reach 10 MDa and its …
[HTML][HTML] Recent advances on surface-modified GBM targeted nanoparticles: targeting strategies and surface characterization
Glioblastoma multiforme (GBM) is the most common malignant brain tumor, associated with
low long-term survival. Nanoparticles (NPs) developed against GBM are a promising …
low long-term survival. Nanoparticles (NPs) developed against GBM are a promising …
[HTML][HTML] Optimization of an injectable hydrogel depot system for the controlled release of retinal-targeted hybrid nanoparticles
A drawback in the development of treatments that can reach the retina is the presence of
barriers in the eye that restrain compounds from reaching the target. Intravitreal injections …
barriers in the eye that restrain compounds from reaching the target. Intravitreal injections …
[HTML][HTML] An Overview of Nanotherapeutic Drug Delivery Options for the Management of Glioblastoma
WH Pentz, VJ Pizzuti, ME Halbert, TJ Plute… - Journal of …, 2023 - mdpi.com
Glioblastoma is the most common primary, malignant brain tumor that remains uniformly
lethal in nearly all cases as a result of extreme cellular heterogeneity, treatment resistance …
lethal in nearly all cases as a result of extreme cellular heterogeneity, treatment resistance …
Challenges of enzyme therapy: Why two players are better than one
S Cuoghi, R Caraffi, A Anderlini… - Wiley …, 2024 - Wiley Online Library
Enzyme‐based therapy has garnered significant attention for its current applications in
various diseases. Despite the notable advantages associated with the use of enzymes as …
various diseases. Despite the notable advantages associated with the use of enzymes as …
[HTML][HTML] Characterization and Functionalization Approaches for the Study of Polymeric Nanoparticles: The State of the Art in Italian Research
Polymeric nanoparticles (PNPs) are a group of nanocarriers employed in a wide range of
applications. Characterization is a fundamental step in PNPs formulation and many basic …
applications. Characterization is a fundamental step in PNPs formulation and many basic …
[HTML][HTML] “Combo” Multi-Target Pharmacological Therapy and New Formulations to Reduce Inflammation and Improve Endogenous Remyelination in Traumatic Spinal …
M Moretti, R Caraffi, L Lorenzini, I Ottonelli, M Sannia… - Cells, 2023 - mdpi.com
Spinal cord injury (SCI) is characterized by a cascade of events that lead to sensory and
motor disabilities. To date, this condition is irreversible, and no cure exists. To improve …
motor disabilities. To date, this condition is irreversible, and no cure exists. To improve …
Strategies for Improved pDNA Loading and Protection Using Cationic and Neutral LNPs with Industrial Scalability Potential Using Microfluidic Technology
I Ottonelli, E Adani, A Bighinati, S Cuoghi… - International Journal …, 2024 - Taylor & Francis
Purpose In recent years, microfluidic technologies have become mainstream in producing
gene therapy nanomedicines (NMeds) following the Covid-19 vaccine; however, extensive …
gene therapy nanomedicines (NMeds) following the Covid-19 vaccine; however, extensive …
Polymer-lipid hybrid nanomedicines to deliver siRNA in and against glioblastoma cells
Small interfering RNA (siRNA) holds great potential to treat many difficult-to-treat diseases,
but its delivery remains the central challenge. This study aimed at investigating the suitability …
but its delivery remains the central challenge. This study aimed at investigating the suitability …
Advanced Nanotechnologies for the Central Nervous System: design, Optimization, Application, and Scale-up
I Ottonelli - 2023 - theses.hal.science
Nanotechnologies, such as nanoparticles (NPs) and nanomedicines (NMeds), show great
promise for treating and diagnosing central nervous system diseases due to features like …
promise for treating and diagnosing central nervous system diseases due to features like …