High-altitude cerebral edema (HACE) and acute mountain sickness (AMS) are
neuropathologies associated with rapid exposure to hypoxia. However, speculation remains …

After ascent to high altitude (≥ 2500 m), the inability of the human body to adapt to the
hypobaric and hypoxia environment can induce tissue hypoxia, then a series of high altitude …

Reduction of aerobic exercise performance observed under hypoxic conditions is mainly
attributed to altered muscle metabolism due to impaired O2 delivery. It has been recently …

This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …

The inability to quantify cerebral blood flow and changes in macrocirculation cross-sectional
area in all brain regions impedes robust insight into hypoxic cerebral blood flow control. We …

Little is known about the ocular and cerebral blood flow during exposure to increasingly
hypoxic conditions at high altitudes. There is evidence that an increase in cerebral blood …

Aquaporin-4, present in ependymal cells, in glia limiting and abundantly in pericapillary
astrocyte foot processes, and aquaporin-1, expressed in choroid plexus epithelial cells, play …

Hypoxic hypoxia (inspiratory hypoxia) stimulates an increase in cerebral blood flow (CBF)
maintaining oxygen delivery to the brain. However, this response, particularly at the tissue …

Acute mountain sickness (AMS) and high-altitude cerebral edema share common clinical
characteristics, suggesting cerebral swelling may be an important factor in the …

Cyclooxygenase (COX) is proposed to regulate cerebral blood flow (CBF); however,
accurate regional contributions of COX are relatively unknown at baseline and particularly …