Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes
A Van Tongelen, A Loriot, C De Smet - Cancer letters, 2017 - Elsevier
Global loss of DNA methylation is frequently observed in the genome of human tumors.
Although this epigenetic alteration is clearly associated with cancer progression, the way it …
Although this epigenetic alteration is clearly associated with cancer progression, the way it …
Basic mechanics of DNA methylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis
J Brocato, M Costa - Critical reviews in toxicology, 2013 - Taylor & Francis
DNA methylation plays an intricate role in the regulation of gene expression and events that
compromise the integrity of the methylome may potentially contribute to disease …
compromise the integrity of the methylome may potentially contribute to disease …
Clinicopathologic comparison of plasmablastic lymphoma in HIV-positive, immunocompetent, and posttransplant patients: single-center series of 25 cases and meta …
J Morscio, D Dierickx, J Nijs, G Verhoef… - The American Journal …, 2014 - journals.lww.com
Plasmablastic lymphoma (PBL) is a rare B-cell non-Hodgkin lymphoma often associated
with Epstein-Barr virus (EBV) infection. To gain insight in this aggressive lymphoma subtype …
with Epstein-Barr virus (EBV) infection. To gain insight in this aggressive lymphoma subtype …
Environmental heat stress induces epigenetic transgenerational inheritance of robustness in parthenogenetic Artemia model
P Norouzitallab, SK Baruah, M Vandegehuchte… - Faseb …, 2014 - biblio.ugent.be
The notion that phenotypic traits emerging from environmental experiences are heritable
remains under debate. However, the recent report of nonmendelian transgenerational …
remains under debate. However, the recent report of nonmendelian transgenerational …
DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45 (CT45) genes is associated with disease progression and reduced survival in epithelial …
Epithelial ovarian cancer (EOC) is a highly lethal malignancy due to a lack of early detection
approaches coupled with poor outcomes for patients with clinically advanced disease …
approaches coupled with poor outcomes for patients with clinically advanced disease …
A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors
A Loriot, A Van Tongelen, J Blanco, S Klaessens… - Epigenetics, 2014 - Taylor & Francis
Genome hypomethylation is a common epigenetic alteration in human tumors, where it often
leads to aberrant activation of a group of germline-specific genes, commonly referred to as …
leads to aberrant activation of a group of germline-specific genes, commonly referred to as …
DNA methylation and nucleosome occupancy regulate the cancer germline antigen gene MAGEA11
MAGEA11 is a cancer germline (CG) antigen and androgen receptor co-activator. Its
expression in cancers other than prostate, and its mechanism of activation, has not been …
expression in cancers other than prostate, and its mechanism of activation, has not been …
Identification of tissue-specific gene clusters induced by DNA demethylation in lung adenocarcinoma: More than germline genes
A Diacofotaki, A Loriot, C De Smet - Cancers, 2022 - mdpi.com
Simple Summary Loss of DNA methylation is often observed in human tumors, but how this
epigenetic alteration impacts the transcriptome of cancer cells remains largely undefined. So …
epigenetic alteration impacts the transcriptome of cancer cells remains largely undefined. So …
Epigenetic Mechanisms Underlying the Dynamic Expression of Cancer-Testis Genes, PAGE2, -2B and SPANX-B, during Mesenchymal-to-Epithelial Transition
S Yilmaz-Ozcan, A Sade, B Kucukkaraduman… - PloS one, 2014 - journals.plos.org
Cancer-testis (CT) genes are expressed in various cancers but not in normal tissues other
than in cells of the germline. Although DNA demethylation of promoter-proximal CpGs of CT …
than in cells of the germline. Although DNA demethylation of promoter-proximal CpGs of CT …
Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription
D Kumari, K Usdin - Human molecular genetics, 2014 - academic.oup.com
The FMR1 gene is subject to repeat mediated-gene silencing when the CGG-repeat tract in
the 5′ UTR exceeds 200 repeat units. This results in Fragile X syndrome, the most common …
the 5′ UTR exceeds 200 repeat units. This results in Fragile X syndrome, the most common …