The colon is derived from the embryological midgut and hindgut separately, with the right
colon and left colon having different features with regards to both anatomical and …

Recent studies have mapped key genetic changes in colorectal cancer (CRC) that impact
important pathways contributing to the multistep models for CRC initiation and development …

Background Given the differences in embryonic origin, vascular and nervous supplies,
microbiotic burden, and main physiological functions of left and right colons, tumor location …

Colorectal cancers (CRCs) form a heterogenous group classified into epigenetic and
transcriptional subtypes. The basis for the epigenetic subtypes, exemplified by varying …

Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal
amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type …

Ethnic differences in non-communicable disease risk have been described between
individuals of South Asian and European ethnicity that are only partially explained by …

Epithelial tissues achieve a highly organized structure due to cell‑cell junction complexes.
Carcinogenesis is accompanied by changes in cell interactions and tissue morphology …

Increasing evidence suggests that left-sided colon cancer (LCC) and right-sided colon
cancer (RCC) are emerging as two different colorectal cancer types with distinct clinical …

Background Ductal carcinoma in situ (DCIS) is a heterogeneous, pre-invasive lesion
associated with an increased risk for future invasive ductal carcinoma. However, accurate …

The pathogenesis of colorectal carcinoma is heterogeneous and involves complex multistep
molecular pathways initiated by genetic and epigenetic events. The molecular classification …