Background In the mouse zygote, DNA methylation patterns are heavily modified, and differ
between the maternal and paternal pronucleus. Demethylation of the paternal genome has …

The cellular mechanisms underlying normal and pathological endometrial bleeding are not
well understood, although abnormalities in the structure of endometrial blood vessels may …

Human endogenous retroviruses (HERV) comprise 8% of the human genome and can be
classified into at least 31 families. A typical HERV provirus consists of internal gag, pol and …

Abstract DNA methyltransferase-1 (Dnmt1) is involved in the maintenance of DNA
methylation patterns and is crucial for normal mammalian development. The aim of the …

Until now, no primate animals have been successfully cloned to birth with somatic cell
nuclear transfer (SCNT) procedures, and little is known about the molecular events that …

Dnmt3a, a de novo methyltransferase, is essential for mammalian germ line DNA
methylation. Only one Dnmt3a is identified in mammals, and homozygous mutants of …

The use of assisted reproductive technology (ART) to overcome fertility problems has
continued to increase since the birth of the first baby conceived by ART over 30 years ago …

It is essential to enhance the in vitro maturation (IVM) condition for immature oocytes after
cryopreservation, particularly if limited numbers of oocytes collected from specific donors …

The present study investigated the global pattern of two histone modifications and
methylation of DNA during in vitro maturation of bovine oocytes retrieved from follicles of two …

A map of human embryo development that combines imaging, molecular, genetic and
epigenetic data for comparisons to other species and across pathologies would be greatly …