Structural mechanisms of transient receptor potential ion channels
E Cao - Journal of General Physiology, 2020 - rupress.org
Transient receptor potential (TRP) ion channels are evolutionarily ancient sensory proteins
that detect and integrate a wide range of physical and chemical stimuli. TRP channels are …
that detect and integrate a wide range of physical and chemical stimuli. TRP channels are …
[HTML][HTML] Calcium homeostasis, transporters, and blockers in health and diseases of the cardiovascular system
G Bkaily, D Jacques - International Journal of Molecular Sciences, 2023 - mdpi.com
Calcium is a highly positively charged ionic species. It regulates all cell types' functions and
is an important second messenger that controls and triggers several mechanisms, including …
is an important second messenger that controls and triggers several mechanisms, including …
[HTML][HTML] The structure of the polycystic kidney disease channel PKD2 in lipid nanodiscs
Summary The Polycystic Kidney Disease 2 (Pkd2) gene is mutated in autosomal dominant
polycystic kidney disease (ADPKD), one of the most common human monogenic disorders …
polycystic kidney disease (ADPKD), one of the most common human monogenic disorders …
[HTML][HTML] Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium
Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …
Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a …
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
M Grieben, ACW Pike, CA Shintre, E Venturi… - Nature structural & …, 2017 - nature.com
Mutations in either polycystin-1 (PC1 or PKD1) or polycystin-2 (PC2, PKD2 or TRPP1) cause
autosomal-dominant polycystic kidney disease (ADPKD) through unknown mechanisms …
autosomal-dominant polycystic kidney disease (ADPKD) through unknown mechanisms …
[HTML][HTML] The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus
Mutations in the polycystin proteins, PC-1 and PC-2, result in autosomal dominant polycystic
kidney disease (ADPKD) and ultimately renal failure. PC-1 and PC-2 enrich on primary cilia …
kidney disease (ADPKD) and ultimately renal failure. PC-1 and PC-2 enrich on primary cilia …
Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2
Abstract Polycystin-2 (PC2), a calcium-activated cation TRP channel, is involved in diverse
Ca2+ signaling pathways. Malfunctioning Ca2+ regulation in PC2 causes autosomal …
Ca2+ signaling pathways. Malfunctioning Ca2+ regulation in PC2 causes autosomal …
The ion channel function of polycystin‐1 in the polycystin‐1/polycystin‐2 complex
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD 1 or
PKD 2 gene, encoding the polycystic kidney disease protein polycystin‐1 and the transient …
PKD 2 gene, encoding the polycystic kidney disease protein polycystin‐1 and the transient …
The cilium as a force sensor− myth versus reality
Cells need to sense their mechanical environment during the growth of developing tissues
and maintenance of adult tissues. The concept of force-sensing mechanisms that act …
and maintenance of adult tissues. The concept of force-sensing mechanisms that act …
Structure and function of polycystins: insights into polycystic kidney disease
D Douguet, A Patel, E Honoré - Nature Reviews Nephrology, 2019 - nature.com
Mutations in the polycystins PC1 or PC2 cause autosomal dominant polycystic kidney
disease (ADPKD), which is characterized by the formation of fluid-filled renal cysts that …
disease (ADPKD), which is characterized by the formation of fluid-filled renal cysts that …