Epigenetic diagnostics of cancer—the application of DNA methylation markers
J Paluszczak, W Baer-Dubowska - Journal of applied genetics, 2006 - Springer
In recent years it has become apparent that epigenetic events are potentially equally
responsible for cancer initiation and progression as genetic abnormalities. DNA methylation …
responsible for cancer initiation and progression as genetic abnormalities. DNA methylation …
Loss of Epigenetic Control of Synuclein-γ Gene as a Molecular Indicator of Metastasis in a Wide Range of Human Cancers
H Liu, W Liu, Y Wu, Y Zhou, R Xue, C Luo, L Wang… - Cancer research, 2005 - AACR
Metastasis is a major contributing factor to poor prognosis in cancer. Reliable and sensitive
biomarkers that indicate the development of metastasis of primary tumors would be of great …
biomarkers that indicate the development of metastasis of primary tumors would be of great …
Clinical potential of DNA methylation in gastric cancer: a meta-analysis
NS Sapari, M Loh, A Vaithilingam, R Soong - PloS one, 2012 - journals.plos.org
Background Accumulating evidence indicates aberrant DNA methylation is involved in
gastric tumourigenesis, suggesting it may be a useful clinical biomarker for the disease. The …
gastric tumourigenesis, suggesting it may be a useful clinical biomarker for the disease. The …
Accurate quantification of DNA methylation using combined bisulfite restriction analysis coupled with the Agilent 2100 Bioanalyzer platform
RM Brena, H Auer, K Kornacker… - Nucleic acids …, 2006 - academic.oup.com
DNA methylation is the best-studied epigenetic modification and describes the conversion of
cytosine to 5-methylcytosine. The importance of this phenomenon is that aberrant promoter …
cytosine to 5-methylcytosine. The importance of this phenomenon is that aberrant promoter …
Colorectal cancer epigenetics: the role of environmental factors and the search for molecular biomarkers
FE Ahmed - Journal of Environmental Science and Health Part C, 2007 - Taylor & Francis
This review presents an evenhanded evaluation of the role of epigenetics in the
development of colorectal cancer, and investigates the extent of environmental influences …
development of colorectal cancer, and investigates the extent of environmental influences …
Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis
Y Zheng, L Chen, J Li, B Yu, L Su, X Chen, Y Yu… - Clinical …, 2011 - Elsevier
OBJECTIVES: To demonstrate the diagnostic significance of methylation, an important
molecular event in gastric carcinogenesis. DESIGN AND METHODS: We used methylation …
molecular event in gastric carcinogenesis. DESIGN AND METHODS: We used methylation …
Fibrillin 2 gene knockdown inhibits invasion and migration of lung cancer cells
Q Hong, R Li, Y Zhang, K Gu - Cellular and Molecular Biology, 2020 - mail.cellmolbiol.org
To investigate the effect of Fibrillin 2 (FBN2) expression on the invasion and migration of
lung cancer cells, and the underlying mechanism. Protein and mRNA expressions of FBN2 …
lung cancer cells, and the underlying mechanism. Protein and mRNA expressions of FBN2 …
The clinical significance of methylation of MAGE-A1 and-A3 promoters and expression of DNA methyltransferase in patients with laryngeal squamous cell carcinoma
S Liu, Y Zhao, Y Xu, M Sang, R Zhao, L Gu… - American Journal of …, 2020 - Elsevier
Purpose Abnormal DNA methylation plays an important role in clinical diagnosis and
prognosis of various tumors. DNA methylation is catalyzed by DNA methyltransferase …
prognosis of various tumors. DNA methylation is catalyzed by DNA methyltransferase …
DNA methylation profiling of blood monocytes in patients with obesity hypoventilation syndrome: effect of positive airway pressure treatment
Background OSA is a highly prevalent condition that is associated with a wide range of long-
term morbidities including metabolic, cardiovascular, and cognitive alterations, possibly via …
term morbidities including metabolic, cardiovascular, and cognitive alterations, possibly via …
Demethylation-mediated upregulation of melanoma-associated antigen-A11 correlates with malignant progression of esophageal squamous cell carcinoma
L Gu, M Sang, J Li, F Liu, Y Wu, S Liu, B Shan - Digestive and Liver …, 2019 - Elsevier
Background The expression and methylation status of oncogenes are closely related to the
onset and progression of cancer. Aims To explore the role and methylation status of …
onset and progression of cancer. Aims To explore the role and methylation status of …