The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …

Pathway enrichment analysis is indispensable for interpreting omics datasets and
generating hypotheses. However, the foundations of enrichment analysis remain elusive to …

Statistical methods for enrichment analysis are important tools to extract biological
information from omics experiments. Although these methods have been widely used for the …

Background Epigenetic clocks can track both chronological age (cAge) and biological age
(bAge). The latter is typically defined by physiological biomarkers and risk of adverse health …

Trained immunity describes the capacity of innate immune cells to develop heterologous
memory in response to certain exogenous exposures. This phenomenon mediates, at least …

PaintOmics is a web server for the integrative analysis and visualisation of multi-omics
datasets using biological pathway maps. PaintOmics 4 has several notable updates that …

Exercise training prevents age‐related decline in muscle function. Targeting epigenetic
aging is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging …

Background Exercise training elicits changes in muscle physiology, epigenomics,
transcriptomics, and proteomics, with males and females exhibiting differing physiological …

Background Experimental studies suggest that exposures may impact respiratory health
across generations via epigenetic changes transmitted specifically through male germ cells …

Background Knowledge of age‐related DNA methylation changes in skeletal muscle is
limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a …