Gastric cancer is one of the most common malignancies and remains the second leading
cause of cancer-related death worldwide. Over 70% of new cases and deaths occur in …

Breast cancer, rather than constituting a monolithic entity, comprises heterogeneous tumors
with different clinical characteristics, disease courses, and responses to specific treatments …

OBJECTIVE: To update the 1997 clinical practice guidelines for the use of tumor marker
tests in the prevention, screening, treatment, and surveillance of breast and colorectal …

Micro-RNAs are small noncoding RNAs, which diminish the stability and/or translation of
mRNAs. This study examined whether miR-206, previously shown to be elevated in …

Formation of transcriptional repression complexes such as DNA methyltransferase (DNMT)
1/histone deacetylase (HDAC) or methyl-CpG binding protein/HDAC is emerging as an …

Abstract Knowledge about breast carcinogenesis has accumulated during the last decades
but has barely been translated into strategies for early detection or prevention of this …

The methylation of DNA is an epigenetic modification that can play an important role in the
control of gene expression in mammalian cells. The enzyme involved in this process is DNA …

The mechanisms underlying hypermethylation of tumor-suppressor gene promoters in
cancer is not well understood. Here, we report that lysine acetylation of the oncogenic …

The physiological effects of progesterone (P) is mediated by two isoforms of progesterone
receptors (PRs): PR-A and PR-B. Progestins have long been used in the treatment of …

Expression of 14-3-3 σ (σ) is induced in response to DNA damage, and causes cells to
arrest in G2. By SAGE (serial analysis of gene expression) analysis, we identified σ as a …