Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

In contrast to the heart or brain, the kidney can completely recover from an ischemic or toxic
insult that results in cell death. During recovery from ischemia/reperfusion injury, surviving …

KIM-1 (kidney injury molecule-1) is a type I transmembrane glycoprotein expressed on
dedifferentiated renal proximal tubule epithelial cells undergoing regeneration after toxic or …

The mammalian kidney is multiform. The basic architecture is best understood in the
unipapillary kidney, which is common in all small species. A coronal section of this kidney …

Proteinuric chronic kidney disease (CKD), once a rare affliction believed to be mainly
caused by genetic mutations, has become a global pandemic that severely diminishes the …

In multicellular organisms, proteins of the extracellular matrix (ECM) play structural and
functional roles in essentially all organs, so understanding ECM protein organization in …

Diabetic nephropathy is an increasingly important cause of morbidity and mortality
worldwide. A large body of evidence suggests that dyslipidemia has an important role in the …

Integrins are transmembrane heteromeric receptors that mediate interactions between cells
and extracellular matrix (ECM). β1, the most abundantly expressed integrin subunit, binds at …