New Findings What is the topic of this review? This review outlines the history of research on
epigenetic adaptations to heat exposure. The perspective taken is that adaptations reflect …

Organisms mount the cellular stress response whenever environmental parameters exceed
the range that is conducive to maintaining homeostasis. This response is critical for survival …

Background Multiple myeloma (MM) is a heterogeneous disease with different patterns of
clonal evolution and a complex tumor microenvironment, representing a challenge for …

Many different lifestyle factors and chemicals present in the environment are a threat to the
reproductive tracts of humans. The potential for parental preconception exposure to alter …

Epigenetic mechanisms such as DNA methylation (DNAme) are thought to comprise an
invaluable adaptive toolkit in the early stages of local adaptation, especially when genetic …

Genome diversity is essential for evolution and is of fundamental importance to human
health. Generating genome diversity requires phases of DNA damage and repair that can …

DNA cytosine methylation in mammals modulates gene expression and chromatin
accessibility. It also impacts mutation rates, via spontaneous oxidative deamination of 5 …

Mammalian genomes are methylated on carbon-5 of many cytosines, mostly in CpG
dinucleotides. Methylation patterns are maintained during mitosis via DNMT1, and …

Mutations in DNA regulatory regions are increasingly being recognized as important drivers
of cancer and other complex diseases. These mutations can regulate gene expression by …

BACKGROUND With the help of ART, an advanced parental age is not considered to be a
serious obstacle for reproduction anymore. However, significant health risks for future …