[HTML][HTML] Predicting gene expression state and prioritizing putative enhancers using 5hmC signal
E Gonzalez-Avalos, A Onodera… - Genome Biology, 2024 - Springer
Background Like its parent base 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC)
is a direct epigenetic modification of cytosines in the context of CpG dinucleotides. 5hmC is …
is a direct epigenetic modification of cytosines in the context of CpG dinucleotides. 5hmC is …
A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia
Z Dong, H Sepulveda, LJA Vazquez, C Blouin… - bioRxiv, 2024 - biorxiv.org
ASXL1 is one of the three most frequently mutated genes in age-related clonal
hematopoiesis (CH), with the others being DNMT3A and TET2. CH can progress to myeloid …
hematopoiesis (CH), with the others being DNMT3A and TET2. CH can progress to myeloid …
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide
H Sepulveda, X Li, X Yue, JC Angel… - bioRxiv, 2024 - biorxiv.org
The O-GlcNAc transferase OGT interacts robustly with all three mammalian TET
methylcytosine dioxygenases. We show here that deletion of the Ogt gene in mouse …
methylcytosine dioxygenases. We show here that deletion of the Ogt gene in mouse …