Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

People are more often exposed to low as opposed to high doses of ionising radiation (IR).
Knowledge on the health risks associated with exposures to ionising radiation above 100 …

The aortic root is the predominant site for development of aneurysm caused by
heterozygous loss-of-function mutations in positive effectors of the transforming growth factor …

Thoracic aortic aneurysms (TAAs) are permanent pathological dilatations of the thoracic
aorta, which can lead to life-threatening complications, such as aortic dissection and rupture …

The angiotensin AT2 receptor (AT 2 R), an important member of the “protective arm” of the
renin-angiotensin system (RAS), has been recently defined as a therapeutic target in …

Aneurysm-osteoarthritis syndrome characterized by unpredictable aortic aneurysm
formation, is caused by SMAD3 mutations. SMAD3 is part of the SMAD2/3/4 transcription …

Aortic aneurysms, including thoracic aortic aneurysms and abdominal aortic aneurysms, are
life-threatening macrovascular diseases with high mortality. The already known key …

Progressive dilation of the infrarenal aortic diameter is a consequence of the ageing process
and is considered the main determinant of abdominal aortic aneurysm (AAA). We aimed to …

Beta-adrenergic receptors (β-AR) are expressed on the membranes of various cell types
and their activation affects body water balance by modulating renal sodium and water …

Aneurysms are local dilations of an artery that predispose the vessel to sudden rupture.
They are often asymptomatic and undiagnosed, resulting in a high mortality rate. The …