The mucosal surfaces of mammals are densely colonized with microorganisms that are
commonly referred to as the commensal microbiota. It is believed that the fetus in utero is …

Pathogen recognition by plants results in the activation of signaling pathways that induce
defense reactions. There is growing evidence indicating that epigenetic mechanisms directly …

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA
expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas …

Many countries are facing the aging of their population, and many more will face a similar
obstacle in the near future, which could be a burden to many healthcare systems. Increased …

Defects in chromatin modifiers and remodelers have been described both for hematological
and solid malignancies, corroborating and strengthening the role of epigenetic aberrations …

Simple Summary Epigenetic mechanisms including methylation play an essential role in
regulating gene expression not only in cancer cells but also in immune cells. Although role …

Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that
uniquely define immune cell types and the mechanisms by which they are established …

Background Umbilical cord blood (UCB) is commonly used in epigenome-wide association
studies of prenatal exposures. Accounting for cell type composition is critical in such studies …