How nutrition and the maternal microbiota shape the neonatal immune system
AJ Macpherson, MG De Agüero… - Nature Reviews …, 2017 - nature.com
The mucosal surfaces of mammals are densely colonized with microorganisms that are
commonly referred to as the commensal microbiota. It is believed that the fetus in utero is …
commonly referred to as the commensal microbiota. It is believed that the fetus in utero is …
Plant immunity: from signaling to epigenetic control of defense
JS Ramirez-Prado, AA Abulfaraj, N Rayapuram… - Trends in plant …, 2018 - cell.com
Pathogen recognition by plants results in the activation of signaling pathways that induce
defense reactions. There is growing evidence indicating that epigenetic mechanisms directly …
defense reactions. There is growing evidence indicating that epigenetic mechanisms directly …
[HTML][HTML] The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery
HG Stunnenberg, S Abrignani, D Adams, M de Almeida… - Cell, 2016 - cell.com
The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …
catalog of high-resolution reference epigenomes of major primary human cell types. The …
[HTML][HTML] Comprehensive analysis of genetic ancestry and its molecular correlates in cancer
We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA
expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas …
expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas …
Markers of T cell senescence in humans
Many countries are facing the aging of their population, and many more will face a similar
obstacle in the near future, which could be a burden to many healthcare systems. Increased …
obstacle in the near future, which could be a burden to many healthcare systems. Increased …
Cancer epigenetics: Moving forward
A Nebbioso, FP Tambaro, C Dell'Aversana… - PLoS genetics, 2018 - journals.plos.org
Defects in chromatin modifiers and remodelers have been described both for hematological
and solid malignancies, corroborating and strengthening the role of epigenetic aberrations …
and solid malignancies, corroborating and strengthening the role of epigenetic aberrations …
Role of methylation in pro-and anti-cancer immunity
A Mehdi, SA Rabbani - Cancers, 2021 - mdpi.com
Simple Summary Epigenetic mechanisms including methylation play an essential role in
regulating gene expression not only in cancer cells but also in immune cells. Although role …
regulating gene expression not only in cancer cells but also in immune cells. Although role …
[HTML][HTML] Genetic and epigenetic regulation of human aging and longevity
Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …
and longevity. Whereas environmental and lifestyle factors are important at younger ages …
[HTML][HTML] DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity
Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that
uniquely define immune cell types and the mechanisms by which they are established …
uniquely define immune cell types and the mechanisms by which they are established …
Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data
Background Umbilical cord blood (UCB) is commonly used in epigenome-wide association
studies of prenatal exposures. Accounting for cell type composition is critical in such studies …
studies of prenatal exposures. Accounting for cell type composition is critical in such studies …