Autism spectrum disorder: neurodevelopmental risk factors, biological mechanism, and precision therapy

L Wang, B Wang, C Wu, J Wang, M Sun - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …

[HTML][HTML] Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders

SB Sartori, N Singewald - Pharmacology & therapeutics, 2019 - Elsevier
Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

Cannabidiol as a potential treatment for anxiety and mood disorders: molecular targets and epigenetic insights from preclinical research

PA Melas, M Scherma, W Fratta, C Cifani… - International journal of …, 2021 - mdpi.com
Cannabidiol (CBD) is the most abundant non-psychoactive component of cannabis; it
displays a very low affinity for cannabinoid receptors, facilitates endocannabinoid signaling …

DNA methylation and schizophrenia: current literature and future perspective

T Magwai, KB Shangase, FO Oginga, B Chiliza… - Cells, 2021 - mdpi.com
Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …

Trends in big data analyses by multicenter collaborative translational research in psychiatry

T Onitsuka, Y Hirano, K Nemoto… - Psychiatry and …, 2022 - Wiley Online Library
The underlying pathologies of psychiatric disorders, which cause substantial personal and
social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core …

Increasing Nrf2 activity as a treatment approach in neuropsychiatry

G Morris, AJ Walker, K Walder, M Berk, W Marx… - Molecular …, 2021 - Springer
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor encoded by NFE2L2.
Under oxidative stress, Nrf2 does not undergo its normal cytoplasmic degradation but …

Exploiting circulating MicroRNAs as biomarkers in psychiatric disorders

B Roy, Y Yoshino, L Allen, K Prall, G Schell… - Molecular diagnosis & …, 2020 - Springer
Non-invasive peripheral biomarkers play a significant role in both disease diagnosis and
progression. In the past few years, microRNA (miRNA) expression changes in circulating …

[HTML][HTML] Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for …

PN Pallier, M Ferrara, F Romagnolo, MT Ferretti… - Progress in …, 2022 - Elsevier
Neurological and neuropsychiatric disorders affect men and women differently. Multiple
sclerosis, Alzheimer's disease, anxiety disorders, depression, meningiomas and late-onset …

[HTML][HTML] Genetic and epigenetic factors associated with depression: An updated overview

DS Alshaya - Saudi journal of biological sciences, 2022 - Elsevier
Depression is a complex psychiatric disturbance involving many environmental, genetic,
and epigenetic factors. Until now, genetic, and non-genetic studies are still on the way to …

Polyphenols as adjunctive treatments in psychiatric and neurodegenerative disorders: Efficacy, mechanisms of action, and factors influencing inter-individual …

G Morris, E Gamage, N Travica, M Berk… - Free Radical Biology …, 2021 - Elsevier
The pathophysiology of psychiatric and neurodegenerative disorders is complex and
multifactorial. Polyphenols possess a range of potentially beneficial mechanisms of action …