In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …

Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …

Tandem 3′ UTRs produced by alternative polyadenylation (APA) play an important role in
gene expression by impacting mRNA stability, translation, and translocation in cells. Several …

DNA methylation is a biochemical process where a DNA base, usually cytosine, is
enzymatically methylated at the 5-carbon position. An epigenetic modification associated …

Aberrant Notch activity is oncogenic in several malignancies, but it is unclear how
expression or function of downstream elements in the Notch pathway affects tumor growth …

Introduction Development of resistance to tamoxifen is an important clinical issue in the
treatment of breast cancer. Tamoxifen resistance may be the result of acquisition of …

DNA methylation was the first epigenetic modification to be detected in human cancers with
specific relation to aberrant gene expression. Herein, DNA methylation analysis explains …

The present study was designed to determine the effects of vitrification on promoter
methylation and the expression levels of pluripotency and differentiation genes in mouse …

OBJECTIVE: To investigate the effect of vitrification on Dnmt1o, Hat1, and Hdac1 promoter
CpG island methylation patterns and messenger RNA (mRNA) expression levels in mouse …

Global changes in DNA methylation correlate with altered gene expression and genomic
instability in cancer. We have developed a methylation-specific digital sequencing (MSDS) …