The heterotrimeric eukaryotic Replication protein A (RPA) is a master regulator of numerous
DNA metabolic processes. For a long time, it has been viewed as an inert protector of …

Growth and proliferation of all cell types require intricate regulation and coordination of
chromosome replication, genome segregation, cell division and the systems that determine …

Three evolutionarily distinct families of replicative DNA polymerases, designated
polymerase B (Pol B), Pol C, and Pol D, have been identified. Members of the Pol B family …

Genetic techniques for the Archaea have undergone a rapid expansion in complexity,
resulting in increased exploration of the role of Archaea in the environment and detailed …

DNA replication is essential for all life forms. Although the process is fundamentally
conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic …

Abstract Together with Bacteria and Eukarya, Archaea represents one of the three domain of
life. In contrast with the morphological difference existing between Archaea and Eukarya …

The archaeal minichromosome maintenance (MCM) has DNA helicase activity, which is
stimulated by GINS in several archaea. In the eukaryotic replicative helicase complex …

Objective The complete picture of how the human microbiome interacts with its host is still
largely unknown, particularly concerning microorganisms beyond bacteria. Although …

In eukaryotic DNA replication initiation, hexameric MCM (mini-chromosome maintenance)
unwinds the template double-stranded DNA to form the replication fork. MCM is activated by …

The polymerase chain reaction (PCR) is widely applied across the biosciences, with
archaeal Family-B DNA polymerases being preferred, due to their high thermostability and …