SUMO: from bench to bedside

HM Chang, ETH Yeh - Physiological Reviews, 2020 - journals.physiology.org
Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates
multiple biological processes, including cell division, DNA replication/repair, signal …

Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts

AB Celen, U Sahin - The FEBS journal, 2020 - Wiley Online Library
Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …

Concepts in sumoylation: a decade on

R Geiss-Friedlander, F Melchior - Nature reviews Molecular cell biology, 2007 - nature.com
A decade has passed since SUMO (small ubiquitin-related modifier) was discovered to be a
reversible post-translational protein modifier. During this time many enzymes that participate …

The nuclear envelope environment and its cancer connections

KH Chow, RE Factor, KS Ullman - Nature Reviews Cancer, 2012 - nature.com
Because of the association between aberrant nuclear structure and tumour grade, nuclear
morphology is an indispensible criterion in the current pathological assessment of cancer …

[HTML][HTML] SUMO-specific protease 1 is essential for stabilization of HIF1α during hypoxia

J Cheng, X Kang, S Zhang, ETH Yeh - Cell, 2007 - cell.com
SUMOylation is a dynamic process, catalyzed by SUMO-specific ligases and reversed by
Sentrin/SUMO-specific proteases (SENPs). The physiologic consequences of SUMOylation …

Modification in reverse: the SUMO proteases

D Mukhopadhyay, M Dasso - Trends in biochemical sciences, 2007 - cell.com
SUMOs (small ubiquitin-like modifiers) are ubiquitin-related proteins that become covalently
conjugated to cellular target proteins that are involved in a variety of processes. Frequently …

[HTML][HTML] SUMOylation and De-SUMOylation: wrestling with life's processes

ETH Yeh - Journal of Biological Chemistry, 2009 - ASBMB
The small ubiquitin-like modifier (SUMO) is a ubiquitin-like protein that covalently modifies a
large number of cellular proteins. SUMO modification has emerged as an important …

[HTML][HTML] Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors

DY Lin, YS Huang, JC Jeng, HY Kuo, CC Chang… - Molecular cell, 2006 - cell.com
Small ubiquitin-like modifier (SUMO) modification has emerged as an important
posttranslational control of protein functions. Daxx, a transcriptional corepressor, was …

Post-translational modifications of nuclear receptors and human disease

M Anbalagan, B Huderson, L Murphy… - Nuclear receptor …, 2012 - journals.sagepub.com
Nuclear receptors (NR) impact a myriad of physiological processes including homeostasis,
reproduction, development, and metabolism. NRs are regulated by post-translational …

[HTML][HTML] SENP proteases as potential targets for cancer therapy

P Tokarz, K Woźniak - Cancers, 2021 - mdpi.com
Simple Summary Post-translational modification—the biochemical addition of functional
groups or proteins—occurs following protein biosynthesis and contributes to an increase in …