The function of vascular endothelial growth factor (VEGF) in cancer is not limited to
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …

Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late
stage, with a 5-yr survival rate of< 30%. The majority of ovarian cancer cases are diagnosed …

Purpose Vascular endothelial growth factor (VEGF) seems to be a promoter of tumor
progression for epithelial ovarian cancer (EOC) and primary peritoneal cancer (PPC). We …

Despite considerable efforts to improve early detection, and advances in chemotherapy,
metastasis remains a major challenge in the clinical management of ovarian cancer. Studies …

Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis which drives
endothelial cell survival, proliferation, and migration while increasing vascular permeability …

Investigations over the last decade have established the essential role of growth factors and
their receptors during angiogenesis and carcinogenesis. The vascular endothelial growth …

Angiogenesis is required in cancer, including gynecological cancers, for the growth of
primary tumors and secondary metastases. Development of anti-angiogenesis therapy in …

Stat3 is constitutively activated in many human cancers where it functions as a critical
mediator of oncogenic signaling through transcriptional activation of genes encoding …

On 13 June 2018, Genentech, Inc. issued a press release announcing that the US FDA had
approved the antiangiogenesis drug, bevacizumab, in combination with chemotherapy for …

Vascular endothelial growth factor (VEGF) proximal promoter region contains a poly G/C-
rich element that is essential for basal and inducible VEGF expression. The guanine-rich …