Genomics, convergent neuroscience and progress in understanding autism spectrum disorder
More than a hundred genes have been identified that, when disrupted, impart large risk for
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …
Genetic insights into the neurodevelopmental origins of schizophrenia
R Birnbaum, DR Weinberger - Nature Reviews Neuroscience, 2017 - nature.com
Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …
neurobiological investigation. Although the underlying causal mechanisms remain …
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak, V Leppa… - Science, 2018 - science.org
The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia
M Prudencio, J Humphrey, S Pickles… - The Journal of …, 2020 - Am Soc Clin Investig
No treatment for frontotemporal dementia (FTD), the second most common type of early-
onset dementia, is available, but therapeutics are being investigated to target the 2 main …
onset dementia, is available, but therapeutics are being investigated to target the 2 main …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data
The etiology of schizophrenia (SCZ) is regarded as one of the most fundamental puzzles in
current medical research, and its diagnosis is limited by the lack of objective molecular …
current medical research, and its diagnosis is limited by the lack of objective molecular …
Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase
Metabolic networks are interconnected and influence diverse cellular processes. The protein-
metabolite interactions that mediate these networks are frequently low affinity and …
metabolite interactions that mediate these networks are frequently low affinity and …
The effects of death and post-mortem cold ischemia on human tissue transcriptomes
PG Ferreira, M Muñoz-Aguirre, F Reverter… - Nature …, 2018 - nature.com
Post-mortem tissues samples are a key resource for investigating patterns of gene
expression. However, the processes triggered by death and the post-mortem interval (PMI) …
expression. However, the processes triggered by death and the post-mortem interval (PMI) …
Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes
Most studies of gene expression in the brains of individuals with schizophrenia have
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …