The classic neurological and psychiatric features associated with vitamin B12 deficiency
have been well described and are the subject of many excellent review articles. The advent …

Protein methylation is a key post-translational modification whose effects on gene
expression have been intensively studied over the last two decades. Recently, renewed …

Methylation reactions linked to homocysteine in the one-carbon metabolism are increasingly
elicited in Alzheimer's disease, although the association of hyperhomocysteinemia and of …

Hyperhomocysteinemia is a recognized risk factor for cognitive decline and incident
dementia in older adults. Two recent reports addressed the cumulative epidemiological …

The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a
multifactorial disease; a strong link between nutritional and genetic factors with normal aging …

Folate is a nutrient essential for the development, function and regeneration of nervous
systems. Folate deficiency has been linked to many neurological disorders including neural …

Pioglitazone is a prototype of thiazolidinediones, used for the treatment of type 2 diabetes
mellitus. Previous studies suggest that pioglitazone might cause DNA damage by …

We have reported that folic acid, vitamin B12, and omega‐3 fatty acids are interlinked in the
one carbon cycle and have implications for fetal programming. Our earlier studies …

There are multiple theories of Alzheimer's disease pathogenesis. One major theory is that
oxidation of amyloid beta (Aβ) promotes plaque deposition that directly contributes to …

Paclitaxel (PAC) is an anticancer drug that has been shown to generate free radicals
leading to irreversible cell injury. Vitamin B12 has antioxidative properties and can protect …