The immune system has to cope with a wide range of irregularly shaped pathogens that can
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …

Phagocytosis is a fundamental process of cells to capture and ingest foreign particles. Small
unicellular organisms such as free-living amoeba use this process to acquire food. In …

The genus Cryptococcus contains two primary species complexes that are significant
opportunistic human fungal pathogens: C. neoformans and C. gattii. In humans …

Cryptococcus neoformans is a significant fungal pathogen of immunocompromised patients.
Many questions remain regarding the function of macrophages in normal clearance of …

Despite significant reductions in morbidity and mortality secondary to availability of effective
combination anti‐retroviral therapy (cART), human immunodeficiency virus (HIV) infection …

The importance of the Basidiomycete Cryptococcus neoformans to human health has
stimulated its development as an experimental model for both basic physiology and …

Cryptococcus neoformans is a facultative intracellular pathogen and its interaction with
macrophages is a key event determining the outcome of infection. Urease is a major …

Central nervous system (CNS) cryptococcosis in non-HIV infected patients affects solid
organ transplant (SOT) recipients, patients with malignancy, rheumatic disorders, other …

Cryptococcus neoformans is an opportunistic pathogenic yeast that causes serious
infections, most commonly of the central nervous system (CNS). C. neoformans is mainly …

Macrophages are innate immune cells that possess unique abilities to polarize toward
different phenotypes. Classically activated macrophages are known to have major roles in …