Cryptococcus species are environmental fungal pathogens and the causative agents of
cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in …

Amoeboid predators, such as amoebae, are proposed to select for survival traits in soil
microbes such as Cryptococcus neoformans; these traits can also function in animal …

The controlled release of antigens from injectable depots has been actively pursued to
achieve long-lasting immune responses in vaccine development. Nonetheless …

Cryptococcus neoformans is a common environmental saprophyte and human fungal
pathogen that primarily causes disease in immunocompromised individuals. Similar to many …

Cryptococcus neoformans is an opportunistic fungal pathogen and a leading cause of death
in immunocompromised individuals. The interactions of this yeast with host phagocytes are …

There is an urgent unmet need for novel antifungals. In this study, we searched for novel
antifungal activities in the Pandemic Response Box, a collection of 400 structurally diverse …

Cryptococcal antigen (CrAg) is detectable in blood prior to the onset of symptomatic
cryptococcal meningitis (CM), a leading cause of death among people with advanced …

Human fungal pathogens are a deadly and underappreciated risk to global health that most
severely affect immunocompromised individuals. A virulence attribute shared by some of the …

The innate immune system is the primary defense against cryptococcal infection, but
paradoxically it promotes infection of the central nervous system. We performed a detailed …

Cryptococcus neoformans (C. neoformans) is an opportunistic fungal pathogen that mainly
infects immunocompromised individuals such as AIDS patients. Although cell surface …