Host cell egress is a critical step in the life cycle of intracellular pathogens, especially in
microbes capable of establishing chronic infections. The Gram-negative bacterium Brucella …

Cryptococcus neoformans is an environmental encapsulated yeast that behaves as an
opportunistic pathogen in immunocompromised individuals. The capsule is the main …

Cryptococcus gattii is an emergent human pathogen. Fluconazole is commonly used for
treatment of cryptococcosis, but the emergence of less susceptible strains to this azole is a …

Cryptococcus neoformans is an environmental yeast that can cause opportunistic infections
in humans. As infecting animals does not form part of its normal life-cycle, it has been …

Being introduced in 2010, fingolimod was among the first oral therapies for relapsing
multiple sclerosis (MS). Since that time, postmarketing surveillance has noted several case …

Microbial pathogens induce or inhibit death of host cells during infection, with significant
consequences for virulence and disease progression. Death of an infected host cell can …

Cryptococcosis is a systemic mycosis that causes pneumonia and meningoencephalitis.
Strongyloidiasis is a chronic gastrointestinal infection caused by parasites of the genus …

Cryptococcus gattii is the main etiological agent of cryptococcosis in immunocompetent
individuals. The triazole drug itraconazole is one of the antifungals used to treat patients with …

Ergosterol, the major sterol in fungal membranes, is critical for defining membrane fluidity
and regulating cellular processes. Although ergosterol synthesis has been well defined in …

Living organisms are constantly exposed to DNA damage stress caused by endogenous
and exogenous events. Eukaryotic cells have evolutionarily conserved DNA damage …