Caspase recruitment domain-containing protein 9 (CARD9) is a critical adaptor molecule
triggered by the interaction of C-type lectin receptors (CLRs) with carbohydrate motifs found …

Macrophages serve as a first line of defense against infection with the facultative
intracellular pathogen, Cryptococcus neoformans (Cn). However, the ability of these innate …

Cryptococcosis is associated with high rates of morbidity and mortality, especially in AIDS
patients. Its treatment is carried out by combining amphotericin B and azoles or flucytosine …

Cryptococcus demonstrates predilection for invasion of the brain, but the mechanism by
which Cryptococcus crosses the blood–brain barrier (BBB) to cause brain invasion is largely …

With over 220,000 cases and 180,000 deaths annually, Cryptococcus neoformans is the
most common cause of fungal meningitis and a leading cause of death in HIV/AIDS patients …

Blastomyces dermatitidis, a dimorphic fungus and the causative agent of blastomycosis, is
widely considered an extracellular pathogen, with little evidence for a facultative intracellular …

Drug resistance is a significant concern in the treatment of diseases, including
cryptococcosis caused by Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga) …

Phagocytosis is an essential component of our immune defence against fungal pathogens.
Differences in the dynamics of phagocyte migration, recognition, uptake and …

Cryptococcal meningitis (CM) is the leading cause of meningitis in much of sub-Saharan
Africa, where it causes up to 20% of all deaths in human immunodeficiency virus (HIV) …

The overuse of antifungal and immunosuppressant drugs and the higher frequency of organ
transplantation has resulted in mycosis being increasingly intractable, and there is a great …