There is surprising confusion surrounding the concept of biological totipotency, both within
the scientific community and in society at large. Increasingly, ethical objections to scientific …

While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

Cytosine DNA methylation (5mC) is a widespread base modification in eukaryotic genomes
with critical roles in transcriptional regulation. In recent years, our understanding of 5mC has …

Upon fertilization, terminally differentiated gametes are transformed to a totipotent zygote,
which gives rise to an embryo. How parental epigenetic memories are inherited and …

Chemical modification of nucleotide bases in DNA provides one mechanism for conveying
information in addition to the genetic code. 5-methylcytosine (5mC) represents the most …

The transition from maternal to zygotic control is fundamental to the life cycle of all
multicellular organisms. It is widely believed that genomes are transcriptionally inactive from …

The awakening of the genome after fertilization is a cornerstone of animal development.
However, the mechanisms that activate the silent genome after fertilization are poorly …

The perception that the inheritance of phenotypic traits operates solely through genetic
means is slowly being eroded: epigenetic mechanisms have been shown to induce …

The changing pattern of granulosa cell expression of inhibin/activin subunits and follistatin
during follicle development and their differential regulation by extrinsic and intraovarian …

Chromatin architecture mapping in 3D formats has increased our understanding of how
regulatory sequences and gene expression are connected and regulated in a genome. The …