Children show important developmental and maturational changes, which may contribute
greatly to pharmacokinetic (PK) variability observed in pediatric patients. These PK …

Antimicrobial resistance has become a significant public health problem globally with
multidrug resistant Gram negative (MDR-GN) bacteria being the main representatives. The …

The limit for possible survival after extremely preterm birth has steadily improved and
consequently, more premature neonates with increasingly lower gestational age at birth now …

Background Many drugs are used off-label or unlicensed in neonates. This does not mean
they are used without evidence or knowledge. We aimed to apply and evaluate the Grading …

Introduction Medicine use in children with cystic fibrosis (CF) is complicated by inconsistent
pharmacokinetics at variance with the general population, a lack of research into this and its …

Introduction There is a need for structured approaches to inform on pharmacotherapy in
preterm neonates. With their proven track record up to regulatory acceptance …

There is currently insufficient knowledge of gestational age dependent medicine disposition
in neonates. Accordingly, the use of off‐label medication, ie, use of medicines outside its …

To truly attain effective and safe pharmacotherapy, the similarities and dissimilarities in
physiology between micro-preemies and extreme preterm infants should be explored. The …

Background Infections are a major cause for morbidity in children with primary or secondary
immunodeficiency, and have a negative impact on overall outcome. Objectives This …

This is an exciting time for research and novel drug development in cystic fibrosis. However,
rarely has the adage,“Children are not just little adults” been more relevant. This article is …