Neuroinflammation is associated with the pathogenesis of many neurological disorders
including Parkinson's disease, Alzheimer's disease, Amyotrophic lateral sclerosis and …

DNA double-strand breaks (DSBs) are highly toxic lesions that can impair cellular
homeostasis and genome stability to result in tumorigenesis for inappropriate repair …

Abstract Background N6-methyladenosine (m6A) is the most prevalent post-transcriptional
modification of eukaryotic mRNA. It has been reported that there is a stimulus-dependent …

Epidemiological studies have shown that traumatic brain injury (TBI) increases the risk for
developing neurodegenerative diseases (NDs). However, molecular mechanisms that …

Aim To assess the effects of subchronic administration with NaHS, an exogenous H 2 S
donor, on TBI-induced hypertension and vascular impairments. Main methods Animals …

Traumatic brain injury (TBI) is an established risk factor for neurodegenerative disorders and
dementias. Epigenetic modifications, such as DNA methylation, may alter the expression of …

Background Cerebral edema and intracranial hypertension are major contributors to
unfavorable prognosis in traumatic brain injury (TBI). Local epigenetic changes, particularly …

It has been widely demonstrated by numerous preclinical studies and clinical trials that the
neonates receiving repeated or long-time general anesthesia (GA) could develop prolonged …

Chronic pain is a common consequence of traumatic brain injury (TBI) that can increase the
suffering of a patient and pose a significant challenge to rehabilitative efforts. Unfortunately …

Abstract N6-甲基腺苷 (N6-methyladenosine, m6A) 甲基化修饰是真核生物 mRNA
最常见的表观遗传修饰之一, 在相关酶的催化调控下, m6A 通过介导 RNA 转录, 剪接, 翻译 …