Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in
the mammalian genome and is essential for embryonic viability. With several of the key …

The methylation of CpG islands is often equated with transcriptional inactivity and there is
overwhelming evidence that this is the case for islands located in gene promoters. Such …

The mechanism responsible for immunoglobulin class switch recombination is unknown.
Previous work has shown that class switch sequences have the unusual property of forming …

Transcriptional silencing in mammals is often associated with promoter methylation.
However, a considerable number of genomic methylated CpGs exist in transposable …

DNA methylation and chromatin modification operate along a common pathway to repress
transcription; accordingly, several experiments demonstrate that the effects of DNA …

The putative de novo methyltransferases, Dnmt3a and Dnmt3b, were reported to have weak
methyltransferase activity in methylating the 3′ long terminal repeat of Moloney murine …

Abstract O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and
mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic …

Cytosine bases are extensively methylated in the DNA of plant genomes. DNA methylation
has been implicated in the silencing of transposable elements and genes, and loss of …

Histone lysine methylation and DNA methylation contribute to transcriptional regulation. We
have previously shown that acetylated histones are associated with unmethylated DNA and …

The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or
apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein …