MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome
due to its high abundance and the frequency of its target sites. It has been the subject of …

Abstracts Genomic DNA is modified in a postreplicative manner and several modifications,
the enzymes responsible for their deposition as well as proteins that read these …

Heterozygous mutations in the X-linked MECP2 gene cause the neurological disorder Rett
syndrome. The methyl-CpG-binding protein 2 (MeCP2) protein is an epigenetic reader …

Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause several
neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the …

Rett syndrome (RTT) is a neurodevelopmental disorder caused predominantly by loss-of-
function mutations in the gene Methyl-CpG-binding protein 2 (MECP2), which encodes the …

Methyl-CpG binding protein 2 (MeCP2) is a multifunctional epigenetic reader playing a role
in transcriptional regulation and chromatin structure, which was linked to Rett syndrome in …

Correlative evidence has suggested that the methyl-CpG-binding protein MeCP2 contributes
to the formation of heterochromatin condensates via liquid-liquid phase separation. This …

Xia–Gibbs syndrome (XGS) is a rare Mendelian disease typically caused by de novo stop‐
gain or frameshift mutations in the AT‐hook DNA binding motif containing 1 (AHDC1) gene …

Histone lysine demethylases (KDMs) play a vital role in regulating chromatin dynamics and
transcription. KDM proteins are given modular activities by its sequence motifs with obvious …

MeCP2 is a nuclear protein that is mutated in the severe neurological disorder Rett
syndrome (RTT). The ability to target β-galactosidase to the nucleus was previously used to …