Gene–environment interactions begin at conception to influence maternal/placental/fetal
triads, neonates, and children with short-and long-term effects on brain development. Life …

Perinatal asphyxia-induced brain injury may present as hypoxic-ischemic encephalopathy in
the neonatal period, and disability including cerebral palsy in the long term. The brain injury …

METHODS: The study was a multicenter, randomized, blinded, controlled, phase IIb trial
investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first …

Anti-epileptic drugs (AEDs) are an important group of drugs of several generations, ranging
from the oldest phenobarbital (1912) to the most recent cenobamate (2019). Cannabidiol …

Outcomes of neonatal encephalopathy (NE) have improved since the widespread
implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE …

Background: Neonatal seizures are a common neurological emergency in newborns.
Phenobarbital (PB) is the first-line antiepileptic drug (AED). However, PB has some side …

Although seizures have a higher incidence in neonates than any other age group and are
associated with significant mortality and neurodevelopmental disability, treatment is largely …

Neonatal Encephalopathy (NE) describes neonates with disturbed neurological function in
the first post-natal days of life. NE is an overall term that does not specify the etiology of the …

Acute symptomatic seizures caused by either diffuse or focal perinatal hypoxic–ischemic
insults and intracranial hemorrhage in term newborns make up the large majority of all …

Convulsive status epilepticus (CSE) is one of the most common pediatric neurological
emergencies. Ongoing seizure activity is a dynamic process and may be associated with …