Background: Phenobarbital and midazolam are commonly used drugs in (near-) term
neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for …

Therapeutic drug monitoring (TDM) should be adopted in all neonatal intensive care units
(NICUs), where the most preterm and fragile babies are hospitalized and treated with many …

Abstract Background and Objectives: Therapeutic interventions to improve the efficacy of
whole-body cooling for hypoxic-ischemic encephalopathy (HIE) are desirable. Topiramate …

Seizures are the most common neurological disorder in newborns and are most prevalent in
the neonatal period. They are mostly caused by severe disorders of the central nervous …

Neonates are exquisitely susceptible to seizures due to several physiologic factors and
combination of risks that are uniquely associated with gestation, delivery, and the immediate …

Sorbitol is a popular sugar alcohol which has been used as an excipient in formulations of
various drugs. Although from a safety perspective the presence of sorbitol in drug …

Background Newborn infants are more prone to seizures than older children and adults. The
neuronal injury caused by seizures in neonates often results in long‐term …

Neonatal encephalopathy (NE) is the most common etiology of acute neonatal seizures–
about half of neonates treated with therapeutic hypothermia for NE have EEG-confirmed …

Background and Purpose—In infants with perinatal arterial ischemic stroke (PAIS), early
prognosis of neurodevelopmental outcome is important to adequately inform parents and …

Objective Seizures are common in neonates recovering from birth asphyxia but there is
general consensus that current pharmacotherapy is suboptimal and that novel antiseizure …