Hypoxic-ischemic encephalopathy (HIE) is the most common cause of neonatal seizures. 1
Seizures in neonates with HIE peak in the first days after birth and are often subclinical. 1 …

Introduction Neonatal seizures are frequent but underdiagnosed manifestations of acute
brain dysfunction and an important contributor to unfavorable outcomes. Etiology and …

Background and objective Phenobarbitone is used as a first-line drug for neonatal seizures.
However, its poor short-and long-term safety profile is concerning. We aim to systematically …

Background Neonatal seizures are frequently encountered in the neonatal intensive care
unit and may be associated with serious long-term neurological sequelae. Response to …

Carboxylesterases (CESs, EC 3.1. 1.1) constitute a large class of enzymes that determine
the therapeutic efficacy and toxicity of ester/amide drugs. Without exceptions, all mammalian …

Objectives To determine the incidence of seizure-like events in a cohort of infants born
preterm as well as the prevalence of associated vital sign changes (heart rate [HR] …

Background Infants who are born from mothers with substance use disorder might suffer
from neonatal abstinence syndrome (NAS) and need treatment with medicines. One of these …

Background Lumbar puncture in the lateral decubitus position will make the neonates
uncomfortable and is likely to cause position change and unstable vital signs, and the …

Background There is growing evidence supporting the safety and effectiveness of
lacosamide in older children. However, minimal data are available for neonates. We aimed …

Results. Data was collected on seven patients. Six patients began having seizures on day
one of life, one had seizures starting on day 45. Different epilepsy etiologies were found. KT …