Chromatin alterations have been associated with all stages of tumour formation and
progression. The best characterized are epigenetically mediated transcriptional-silencing …

The field of cancer epigenetics is evolving rapidly on several fronts. Advances in our
understanding of chromatin structure, histone modification, transcriptional activity and DNA …

Hypermethylation of CpG islands in the promoter regions is an important mechanism to
silence the expression of many important genes in cancer. The hypermethylation status is …

In the present investigation, we studied the modulating effects of several tea catechins and
bioflavonoids on DNA methylation catalyzed by prokaryotic SssI DNA methyltransferase …

Plants produced vegetatively in tissue culture may differ from the plants from which they
have been derived. Two major classes of off-types occur: genetic ones and epigenetic ones …

Among many anticancer drugs collectively named “targeted or molecular therapies”
epigenetic drugs are clearly promising. Differently from other agents targeting a single gene …

Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with
many human tumour types. New techniques have been developed to perform genome-wide …

We studied the modulating effects of caffeic acid and chlorogenic acid (two common coffee
polyphenols) on the in vitro methylation of synthetic DNA substrates and also on the …

This work is dedicated to the development of a technology for unbiased, high-throughput
DNA methylation profiling of large genomic regions. In this method, unmethylated and …

Cervical cancer remains one of the greatest killers of women worldwide. It is difficult to
foresee a dramatic increase in cure rate even with the most optimal combination of cytotoxic …