The complexity of the mammalian genome is regulated by heritable epigenetic mechanisms,
which provide the basis for differentiation, development and cellular homeostasis. These …

Chromatin folding and dynamics are critically dependent on nucleosome–nucleosome
interactions with important contributions from internucleosome binding of the histone H4 N …

Introduction: Epidemiological studies indicate that diet rich in fruits and vegetables is
associated with decreased cancer risk thereby indicating that dietary polyphenols can be …

Abstract Objectives Systemic sclerosis (SSc) is associated with secondary malignancies.
Previous studies have suggested that mutated cancer proteins, such as RNA polymerase III …

The 'language'of covalent histone modifications translates environmental and cellular cues
into gene expression. This vast array of post-translational modifications on histones are …

Post‐translational modification of proteins is ubiquitous and mediates many cellular
processes, including intracellular localization, protein–protein interactions, enzyme activity …

Peroxisome proliferator-activated receptor gamma (PPARG) inactivation has been identified
as an important step in colorectal cancer (CRC) progression, although the events involved …

Traditionally, cancer has been viewed as a set of diseases that are driven by the
accumulation of genetic mutations, but we now understand that disruptions in epigenetic …

Alterations of epigenetic modifications are promising targets for cancer therapy, and several
epigenetic drugs are now being clinically utilized. At the same time, individual epigenetic …

Autophagy, an evolutionary conserved multifaceted lysosome-mediated bulk degradation
system, plays a vital role in liver pathologies including hepatocellular carcinoma (HCC). Post …