Recent preclinical studies have shown the feasibility of specific variants of nuclear transfer to
prevent mitochondrial DNA disorders. Nuclear transfer could be a valuable reproductive …

Abstract BACKGROUND Mitochondrial DNA (mtDNA) disorders are an important cause of
human diseases. In view of the limitations of prenatal diagnosis and preimplantation genetic …

In March 2005, a group of experts from the European Society of Human Genetics and
European Society of Human Reproduction and Embryology met to discuss the interface …

The inability to support the growth and development of a mature fetus up to delivery results
in significant human suffering. Current available solutions include adoption, surrogacy, and …

In this review we aim to provide an overview of the most important ethical pros and cons of
stem cell derived gametes (SCD-gametes), as a contribution to the debate about …

Preimplantation genetic diagnosis (PGD) for monogenic diseases has known a
considerable evolution since its first application in the early 1990s. Especially the technical …

BACKGROUND The demand for donor oocytes has increased dramatically over the years.
Today people in need of ART with the use of donor oocytes can appeal to commercial or …

Mitochondrial disease resulting in reduced bioenergetic output can be due to mutations in
either nuclear DNA–encoded or mitochondrial DNA–encoded gene products. We …

Over the years, the demand for ART with donated embryos has increased. Treatment can be
performed using donated 'surplus embryos' from IVF treatment or with embryos intentionally …

BACKGROUND Although sexual activity has, until very recently, been essential to
reproduction, this did not preclude the non-reproductive importance of sexual relationships …