A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder
Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs
cognition. A gene potentially important to this disorder is the brain derived neurotrophic …
cognition. A gene potentially important to this disorder is the brain derived neurotrophic …
DNA methylation and application in forensic sciences
F Kader, M Ghai - Forensic science international, 2015 - Elsevier
DNA methylation of cytosine residues is a stable epigenetic alteration, beginning as early as
foetal development in the uterus and continuously evolving throughout life. DNA methylation …
foetal development in the uterus and continuously evolving throughout life. DNA methylation …
Predicting genome-wide DNA methylation using methylation marks, genomic position, and DNA regulatory elements
Background Recent assays for individual-specific genome-wide DNA methylation profiles
have enabled epigenome-wide association studies to identify specific CpG sites associated …
have enabled epigenome-wide association studies to identify specific CpG sites associated …
Changes in correlation between promoter methylation and gene expression in cancer
Background Methylation of high-density CpG regions known as CpG Islands (CGIs) has
been widely described as a mechanism associated with gene expression regulation …
been widely described as a mechanism associated with gene expression regulation …
Redefining CpG islands using hidden Markov models
The DNA of most vertebrates is depleted in CpG dinucleotide: a C followed by a G in the 5′
to 3′ direction. CpGs are the target for DNA methylation, a chemical modification of …
to 3′ direction. CpGs are the target for DNA methylation, a chemical modification of …
Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero
Mercury and arsenic are known developmental toxicants. Prenatal exposures are
associated with adverse childhood health outcomes that could be in part mediated by …
associated with adverse childhood health outcomes that could be in part mediated by …
Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia
P Yan, D Frankhouser, M Murphy… - Blood, The Journal …, 2012 - ashpublications.org
The outcome of older (≥ 60 years) acute myeloid leukemia (AML) patients is poor, and
novel treatments are needed. In a phase 2 trial for older AML patients, low-dose (20 mg/m2 …
novel treatments are needed. In a phase 2 trial for older AML patients, low-dose (20 mg/m2 …
Comprehensive analysis of regulation of DNA methyltransferase isoforms in human breast tumors
Significant reprogramming of epigenome is widely described during pathogenesis of breast
cancer. Transformation of normal cell to hyperplastic cell and to neoplastic phenotype is …
cancer. Transformation of normal cell to hyperplastic cell and to neoplastic phenotype is …
An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis
Oxytocin is a neuropeptide hormone which is involved in regulation of social behavior,
stress response, muscle contraction, and metabolism. Oxytocin signaling is dependent on its …
stress response, muscle contraction, and metabolism. Oxytocin signaling is dependent on its …
[HTML][HTML] HPV-related oropharyngeal cancer and biomarkers based on epigenetics and microbiome profile
S Gougousis, E Mouchtaropoulou, I Besli… - Frontiers in Cell and …, 2021 - frontiersin.org
H uman papillomavirus (HPV) is considered the main cause of the increasing incidence
rates of oropharyngeal squamous cell carcinoma (OPSCC), and soon, the global burden of …
rates of oropharyngeal squamous cell carcinoma (OPSCC), and soon, the global burden of …