The primary cause of cancer-related death from solid tumors is metastasis. While unraveling
the mechanisms of this complicated process continues, our ability to effectively target and …

With few exceptions, metastasis is the terminal stage of cancer with limited therapeutic
options. Metastasis consists of numerous phenotypic and genotypic alterations of cells that …

Many clinical studies have shown that embryos of in vitro fertilization (IVF) are often prone to
developmental arrest, which leads to recurrent failure of IVF treatment. Early embryonic …

An extraordinary binding site generated in heparan sulfate (HS) structures, during its
biosynthesis, provides a unique opportunity to interact with multiple protein ligands including …

Histone lysine methylation is important in early zebrafish development; however, the role of
histone arginine methylation in this process remains unclear. H3R2me2a, generated by …

Podocytes are highly specialized epithelial cells that are essential for an intact glomerular
filtration barrier in the kidney. Several glomerular diseases like focal segmental …

Human embryos of in vitro fertilization (IVF) are often susceptible to developmental arrest,
which greatly reduces the efficiency of IVF treatment. In recent years, it has been found that …

Epiboly spreads and thins the blastoderm over the yolk cell during zebrafish gastrulation.
Despite of its fundamental function, little is known about the molecular mechanisms that …

Podocytes are highly specialized kidney cells that are attached to the outer aspect of the
glomerular capillaries and are damaged in more than 75% of patients with an impaired renal …

Arginine methylation is an important posttranslational modification and catalyzed by a family
of protein arginine methyltransferases (PRMTs). PRMT7 is the type III PRMT and produces …