Objectives A number of randomised control trials (RCTs) investigating the effects of long-
acting somatostatin analogues in autosomal dominant polycystic kidney disease (ADPKD) …

Background/Aims: Experimental and clinical evidence suggested that monocyte
chemoattractant protein-1 (MCP-1/CCL2) has a role in the development of interstitial …

Vasopressin and V2 receptor signaling promote polycystic kidney disease (PKD)
progression, raising the question whether suppression of vasopressin release through …

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic
disorders worldwide. In recent decades, the field has undergone a revolution, starting with …

ADPKD is a genetic disorder with a molecular complexity that remains poorly understood. In
this study, we sampled renal cells to construct a comprehensive and spatiotemporally …

A primary pathological feature of polycystic kidney disease (PKD) is the hyperproliferation of
epithelial cells in renal tubules, resulting in formation of fluid-filled cysts. The proliferative …

Cyclic AMP promotes cyst growth in polycystic kidney disease (PKD) by stimulating cell
proliferation and fluid secretion. Previously, we showed that the primary cilium of renal …

The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that
regulates electrolyte and fluid balance in epithelial tissues. While activation of CFTR is vital …

Autosomal dominant polycystic kidney disease (ADPKD) is a common heritable human
disease. Recently, the role of repressed autophagy in ADPKD has drawn increasing …

Clinical and fundamental research suggest that altered calcium and cAMP signaling might
be the most proximal events in ADPKD pathogenesis. Cells from ADPKD cysts have a …